WASHINGTON, NNC - US Senator John McCain, who ran twice for US presidency, died at 81 on Saturday at his home in the State of Arizona, his office said in a statement.
"Senator John Sidney McCain III died at 4:28 p.m. (2328 GMT) on August 25, 2018. With the senator when he passed were his wife Cindy and their family," the statement said.
McCain suffered from a malignant brain cancer and had been treated regularly with radiation and chemotherapy since his disease was discovered in 2017.
His family announced on Friday that McCain had stopped further treatment of his cancer.
"My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years. He passed the way he lived, on his own terms, surrounded by the people he loved, in the the place he loved best," Cindy McCain wrote on Twitter.
McCain has appeared publicly since the 1960s, when as a Navy pilot his plane was shot down during the Vietnam War and tortured when he was held prisoner by the North Vietnamese communists for 5.5 years.
He was defeated by George W. Bush for the Republican presidential nomination in 2000, but became his party's candidate to inhabit the White House eight years later. After competing in politics with Sarah Palin as her vice-presidential candidate, McCain lost in 2008 to Democratic candidate Barack Obama - the first black citizen to become US president, Antara reported.