JAKARTA, NETRALNEWS.COM - Therapy using nicotinamide or niacin which is made of vitamin B3 has the potential to prevent melanoma--a deadly skin cancer--according to scientists. Researchers from the University of Sydney in Australia found that nicotinamide may help reduce or reverse DNA damage, swelling, and immune suppression caused by ultraviolet radiation.
The cost of nicotinatimide is about $10 per month or about IDR132,000, if consumed one gram per day as recommended, said the researcher.
"A randomized, placebo-controlled trial is now needed to determine its effectiveness and safety for melanoma prevention," said Gary Halliday from the University of Sydney, as quoted by Boldsky, Saturday (8/12/2017).
Ultraviolet radiation (UVR) causes DNA damage to melanocytes by producing photolesions (lesions due to exposure to light) such as pyrimidine cyclobutane dimer and 8-oxo-7-hydrodeoxyguanosine.
Production of reactive oxygen species by UVR also induces inflammatory cytokines (a category of proteins) which, together with immunosuppressive properties attached to UVR, propagate carcinogenesis (formation of cancer), the researchers said.
Nicotinamide improves DNA repair, modulates the inflammatory environments produced by UVR, and reduces UV-induced immunosuppression.
Because nicotinamide reduces the incidence of actinic keratosis, also called solar keratosis, and non-melanoma skin cancer in high-risk individuals and improves DNA repair damage to melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations.
"Nicotinamide has been shown in clinical trials--called ONTRAC--to reduce the incidence of non-melanoma skin cancer in high-risk individuals and will be useful to determine whether it is also beneficial for high-risk melanoma patients," he said.
The research was published in Photodermatology, Photoimmunology and Photomedicine. (*)